Electrospinning of animal-free derived collagen-like protein: Development and characterization of VECOLLAN®- nanofibers for biomedical applications.

ABSTRACT: This study investigates the potential of VECOLLAN®, a recombinant, novel, non-animal-derived collagen-like protein, for use in electrospinning applications relevant to biomedical and drug delivery sectors. Given the limitations of animal-derived collagens, including immunogenicity and variability, VECOLLAN® offers a promising alternative due to its biotechnological production and non-immunogenic, non-allergenic, and non-inflammatory properties. We optimized the electrospinning parameters for VECOLLAN® and examined the effects of a novel coaxial crosslinking approach on the dissolution and disintegration behaviors of the resultant fibers. Our results demonstrate that VECOLLAN®-based fibers can achieve varying degrees of water insolubility, influenced by crosslinker concentration and type of

SUBMITTER: Krauss C 

PROVIDER: S-EPMC12510221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature