Anisotropic light propagation in human brain white matter.

ABSTRACT:

Significance

Accurate modeling of light diffusion in the human brain is crucial for applications in optogenetics and spectroscopic diagnostic techniques. White matter tissue is composed of myelinated axon bundles, suggesting the occurrence of enhanced light diffusion along their local orientation direction, which however has never been characterized experimentally. Existing diffuse optics models assume isotropic properties, limiting their accuracy.

Aim

We aim to characterize the anisotropic scattering properties of human white matter tissue by directly measuring its tensor scattering components along different directions and correlating them with the local axon fiber orientation.

Approach

Using a time- and space-resolved setup, we image the transverse propagation of d

SUBMITTER: Pini E 

PROVIDER: S-EPMC12510258 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature