Intratympanic dexamethasone microcrystal-loaded porous PLGA microspheres containing lipoic acid for combined delivery to the inner ear.

ABSTRACT:

Objective

To develop a sustained-release codelivery system for intratympanic administration of dexamethasone (DEX) and lipoic acid (LA).

Methods

DEX microcrystals (MCs) were prepared via precipitation, while LA-loaded porous PLGA microspheres (LPMPs) were fabricated using a double emulsion-solvent evaporation method. DEX MCs were physically perfused into LPMPs via negative pressure to form a combined system (DEX MCs+LPMPs). Physicochemical properties, in vitro drug release, pharmacokinetics, and biocompatibility were evaluated. Guinea pigs were used for intratympanic injections of DEX MCs, LPMPs, or DEX MCs+LPMPs.

Results

The DEX MCs+LPMPs system enabled simultaneous release of both drugs, with DEX exhibiting superior pharmacokinetics (sustained perilymph conce

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12510363 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature