Unusual "mesoionic" N^S biscyclometallated iridium(iii) polypyridine complexes as photosensitisers for photodynamic therapy and type II immunogenic cell death inducers.

ABSTRACT: Historically, the classification of mesoionic compounds has been disconcerting, with more confusion arising when these molecules are used as ligands for metal complexes. Many mesoionic compounds are also biologically active and widely used in various therapeutic applications, but mesoionic metal complexes have not seen much prevalence in the field. In this work, we determine the "mesoionic" nature of an unusual and rare series of N^S biscyclometallated iridium(iii) complexes [Ir(N^C)₂(p-ttqt)] (p-Httqt = 1-phenyl-5-thioxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolin-1-ium-2-thiolate; HN^C = 2-phenylpyridine (Hppy) (1), 7,8-benzoquinoline (Hbzq) (2), 2-phenylbenzothiazole (Hbt) (3) and 2-(1-naphthyl)benzothiazole (Hbsn) (4)) as photodynamic therapy (PDT) agents and immunog

SUBMITTER: Shum J 

PROVIDER: S-EPMC12510370 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature