Two-step localization driven by peptidoglycan hydrolase in interbacterial predation.

ABSTRACT: Mechanisms of bacterial predation are crucial for revealing microbial adaptation strategies and interaction behaviors in the environment, yet they remain poorly understood. Previously, predators were reported to localize prey via specific cues. However, the process and mechanisms by which these cues, including signaling molecules, mediate predator localization remain unclear. Herein, we investigate the dynamic interaction between the predatory bacteria Lysobacter enzymogenes and its prey bacteria. By integrating genetic manipulation, transcriptomic analysis, biochemical assays, and live-cell tracking microscopy at the single-cell level, we present a novel predation strategy mediated by peptidoglycan hydrolase LssL, named peptidoglycan hydrolase-driven Prey Localization and Utilization Syst

SUBMITTER: Song H 

PROVIDER: S-EPMC12510463 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature