Pharmacoinvasive strategy versus fibrinolytic therapy alone in adults with ST-elevation myocardial infarction: A systematic review and meta-analysis.

ABSTRACT:

Objective

To compare the pharmacoinvasive strategy (PS) versus fibrinolysis alone in adults with ST-segment elevation myocardial infarction.

Methods

We searched PubMed/MEDLINE, Web of Science, Embase, and Cochrane Library from inception until January 17th, 2025. The review protocol was registered in PROSPERO (CRD42022309130). We included randomized controlled trials (RCTs), assessed risk of bias with the Cochrane Risk of Bias 1.0 tool, and calculated pooled relative risks and mean differences. We used GRADE's minimally contextualized approach to determine the certainty of the evidence.

Results

We found 7 RCTs (n = 3053). The PS, compared to fibrinolysis alone, may have an important reduction on mortality (3.3% vs 3.9%; -5 per 1000; 95% CI: -16 to +10); and has an impo

SUBMITTER: Soriano-Moreno DR 

PROVIDER: S-EPMC12510495 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature