Challenges in explaining deep learning models for data with biological variation.

ABSTRACT: Much machine learning research progress is based on developing models and evaluating them on a benchmark dataset (e.g., ImageNet for images). However, applying such benchmark-successful methods to real-world data often does not work as expected. This is particularly the case for biological data where we expect variability at multiple time and spatial scales. Typical benchmark data has simple, dominant semantics, such as a number, an object type, or a word. In contrast, biological samples often have multiple semantic components leading to complex and entangled signals. Complexity is added if the signal of interest is related to atypical states, e.g., disease, and if there is limited data available for learning. In this work, we focus on image classification of real-world biological data tha

SUBMITTER: Tetkova L 

PROVIDER: S-EPMC12510501 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature