Pro-inflammation and clinical correlates of unsuppressed HIV-viral load in children living with perinatally-acquired HIV 1 in Zambia.

ABSTRACT:

Background

Children living with perinatally-acquired HIV-1 (CPHIV) face significant health challenges despite advancements in antiretroviral therapy (ART). This study aimed to determine the association between unsuppressed HIV RNA viral load (VL), proinflammatory markers, sociodemographic, and clinical factors among CPHIV attending routine ART clinic at Arthur Davison Children's Hospital (ADH), Ndola, Zambia.

Methods

We conducted a cross-sectional study on 135 CPHIV, aged 2-18 years, who had been on ART for over 12 months. Sociodemographic, clinical, and laboratory data were collected using a standardized questionnaire and a data collection form. The primary outcome was unsuppressed HIV RNA VL defined as a viral load greater than 1000 copies/mL of HIV-1 RNA after at least 6

SUBMITTER: Nzobokela J 

PROVIDER: S-EPMC12510508 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature