Exploring the impact of antibody-dependent cellular phagocytosis-related genes on the prognosis of metastatic melanoma.

ABSTRACT:

Background

Metastatic melanoma is a challenging clinical condition with poor prognosis. Recent research has highlighted the role of antibody-dependent cellular phagocytosis (ADCP) in tumor immunity, suggesting prognostic implications for ADCP-related genes (ARGs). This study develops a prognostic model for metastatic melanoma using ARGs to enhance clinical decision-making and therapeutic strategies.

Methods

Prognostic ARGs were identified from the GSE46517 and GSE7553 datasets. A prognostic model was constructed using LASSO-Cox regression and validated across multiple cohorts, including TCGA and GEO datasets. A nomogram was developed to assess survival outcomes in metastatic melanoma patients. Functional assays, including siRNA knockdown of DOCK10 in A375 cells, were conduct

SUBMITTER: Chen J 

PROVIDER: S-EPMC12510546 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature