Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool.

ABSTRACT:

Background

Early-onset sepsis (EOS) remains a leading cause of mortality and neurodevelopmental injury in preterm infants, yet widely used tools (e.g., Kaiser EOS Calculator) are not designed for <35-37 weeks' gestation.

Objective

To develop and internally validate a concise, clinically interpretable nomogram for EOS risk stratification in preterm neonates and to evaluate its potential for antibiotic stewardship.

Methods

We performed a single-center retrospective cohort study (July 2023-June 2024) including 1,059 preterm infants admitted within 72 h of birth, randomly split 7:3 into training (n = 742) and validation (n = 317). Forty-five maternal and neonatal candidates were screened (univariable tests, LASSO), followed by multivariable logistic regression to build th

SUBMITTER: Guo L 

PROVIDER: S-EPMC12510551 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature