PRMT5 genetic interactions with DNA double strand break repair genes.

ABSTRACT: Protein arginine methyltransferase 5 (PRMT5) has pleiotropic functions in human cells but also participates in orchestrating DNA double strand break (DSB) repair. It methylates the TIP60 histone acetyltransferase complex to facilitate recruitment to the DSB and chromatin remodeling. PRMT5 mutations affect DSB repair by homologous recombination and increase chromosomal instability. In this report we characterized genetic interactions between PRMT5 mutations and mutations in other components of DSB repair pathway. We used data deposited on the Catalogue of Somatic Mutations in Cancers (COSMIC). We found that PRMT5 makes negative genetic interactions with TIP60 and member of the 9-1-1 complex (RAD9, RAD1, HUS1) which is required for checkpoint activation. A comprehensive analysis of all cance

SUBMITTER: Bliss HJ 

PROVIDER: S-EPMC12510555 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature