Combined metabolomics and proteomics analysis of vascular cognitive impairment in hypertensive rats induced by endothelial injury.

ABSTRACT:

Aim

Based on metabolomics and proteomics research, we investigate the molecular biological mechanisms underlying vascular cognitive impairment (VCI) in rats induced by hypertension combined with endothelial damage, aiming to identify proteins or metabolites associated with key metabolic pathways.

Methods

SPF hypertensive rats (SHR) were used to damage the common carotid artery endothelium with microcurrent to induce vascular cognitive impairment model in rats (Model group), SHR rats (SHR group) and SPF normotensive Wistar-Kyoto rats (WKY) with the same genetic background were used as sham operation groups (no current stimulation after dissection), with 10 rats in each group. Morris water maze, PNT experiment and SPT experiment were used to detect the learning and memory abil

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12510566 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature