Immune repertoire profiling and T cell dysregulation in Peripheral Blood Mononuclear Cells of Type 2 diabetic patients.

ABSTRACT:

Objective

The prevalence of diabetes mellitus (DM) is escalating globally, presenting a significant public health challenge. The immune system, particularly T cells, plays a crucial role in the pathogenesis of diabetes. This study aims to elucidate the characteristics of T cell receptors (TCRs) and immune dysregulation within peripheral blood mononuclear cells (PBMCs) of diabetic patients, with exploratory analysis of microbial profiles.

Methods

We employed high-throughput RNA-seq to analyze the protein-coding genes expression, and function enrichment with different expression, BCR/TCR repertoires and microbial communities in PBMC samples collected from both diabetic patients and healthy controls. Comparative analysis was conducted to identify distinct TCR signatures associa

SUBMITTER: Bi Z 

PROVIDER: S-EPMC12510570 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature