The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release.

ABSTRACT: Candida albicans, an opportunistic fungal pathogen, causes systemic and superficial infections, especially in immunocompromised patients. Treatment of fungal infections is complicated by limited antifungal options and the development of drug resistance. Previous work from our group demonstrated the efficacy of the anti-virulence peptide EntV and shorter variants against C. albicans infection in various animal models, including mouse models of oropharyngeal candidiasis and disseminated infection and a rat venous catheter model. However, the mechanism of action, which abrogates fungal virulence without fungicidal or fungistatic activity, has remained unknown. We used a combination of cell biological, biochemical, genomic, and genetic approaches to identify this mechanism. We demonstrate that

SUBMITTER: Buda De Cesare G 

PROVIDER: S-EPMC12510648 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature