Congenital transmission of Chagas disease by vector circulation zone in Bolivia.

ABSTRACT:

Background

Bolivia has one of the highest burdens of Chagas disease. Transmission is most common through the triatomine bug vector carrying Trypanosoma cruzi infection, but a rising proportion of cases occurs through congenital transmission from mother to infant. Women living in endemic regions with high vector circulation are known to have an elevated risk of Chagas disease, but the relative risk of congenital transmission is unclear.

Methods

We performed a prospective observational study of pregnant women with Chagas disease and their infants at 11 hospitals in Bolivia from September 2020 to March 2023. High vector circulation zones were defined as having triatomine infestation in >3% of local homes. Congenital Chagas disease was diagnosed in infants using polymerase chain

SUBMITTER: Rodriguez BA 

PROVIDER: S-EPMC12510653 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature