The probability of Plasmodium vivax acute illness following primary infection and relapse in Papua New Guinea.

ABSTRACT: Inoculation with Plasmodium vivax malaria parasites can lead to blood-stage infections from the primary infection and relapses from liver-stage parasites or non-circulating merozoites. Understanding the risk of clinical illness following primary infection and relapse would inform surveillance and intervention strategies, but the probabilities are uncertain in people living in endemic areas. A major difficulty lies in the inability to distinguish primary infections and relapses. In this study, we estimate the probabilities of clinical illness using the different seasonal patterns of primary infection and relapse. Children aged one to three years in Ilaita, Papua New Guinea, were followed up over 16 months for illness (fever with ≥500 parasites/µl) with fortnightly active and passive case de

SUBMITTER: Ross A 

PROVIDER: S-EPMC12510656 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature