Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex.

ABSTRACT: Recent studies have highlighted axonal myelination as a common feature of parvalbumin-positive (PV) interneurons throughout the cerebral cortex. However, the precise function of PV interneuron myelination remains incompletely understood. In this study, we used the cuprizone model of demyelination in mice to investigate how PV interneuron myelination might influence their neuronal physiology. Specifically, we examined whether impairing myelination from postnatal day 21 onwards, during a critical neurodevelopmental period of the prefrontal cortex (PFC), can affect PV interneuron maturation and function. Using whole-cell patch-clamp recordings to examine intrinsic properties of PV interneurons in the PFC, we found that juvenile demyelination in mice induced robust alterations of PV interneuro

SUBMITTER: Hijazi S 

PROVIDER: S-EPMC12510662 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature