Temporal and spatial profiling of Aedes albopictus immune responses to chikungunya virus infection.

ABSTRACT: The global expansion of Aedes albopictus from Southeast Asia to various regions worldwide poses a significant public health concern due to its role as a vector for several pathogens, including chikungunya virus (CHIKV), which infects over one million people annually. In this study, aimed at understanding the molecular interactions between Ae. albopictus and CHIKV, we analyzed by RNA sequencing CHIKV-infected and uninfected control mosquitoes. We focused our attention on key mosquito organs at one- and five-days post-blood meal ingestion, which correspond to viral entry and dissemination, and found specific transcriptional changes involving various pathways during the CHIKV lifecycle. The mosquito midgut plays a crucial role in the early stages, when the virus enters along with human blood

SUBMITTER: Dipaola MG 

PROVIDER: S-EPMC12510663 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature