Antibiotic-induced morphological changes enhance phage predation.

ABSTRACT: Due to the high public health risk posed by antibioresistance, phage therapy - the use of bacteriophages as antibacterial agents - is experiencing renewed interest. As the combined administration of antibiotics and phages is a common practice in compassionate treatments, our research focuses on the effects of antibiotics on phage predation, which may be of crucial importance for phage therapeutic applications. A distinctive manifestation of phage infection in solid media is the appearance of lysis plaques, corresponding to the circular thinning of a bacterial lawn. During plaque formation, successive cycles of phage replication take place from a single point of infection and spread radially in a lawn of immobilized bacterial hosts. Many factors affect plaque size, such as the composition a

SUBMITTER: Bulssico J 

PROVIDER: S-EPMC12510666 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature