Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity.

ABSTRACT: Muscular strength has been positively associated with better brain health indicators during childhood obesity. However, the molecular mechanisms underlying the positive impact of muscular strength in brain health are poorly understood. We aimed to study the association of muscular strength with neurology-related circulating proteins in plasma in children with overweight/obesity and to explore the role of cardiorespiratory fitness (CRF) as a confounder. The participants were 86 Caucasian children (10.1 ± 1.1 years old; 41% girls) from the ActiveBrains project. Muscular strength was measured by field and laboratory tests. CRF was assessed with an incremental treadmill test. Olink's technology was used to quantify 92 neurology-related proteins in plasma. Protein-protein interactions were comp

SUBMITTER: Olvera-Rojas M 

PROVIDER: S-EPMC12510670 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature