Yi-Qi-Xuan-Fei Formula ameliorate chronic obstructive pulmonary disease by remodeling lung and intestinal florase in rat models.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by various pathological lesions and an imbalance in the microflora. The Yi-Qi-Xuan-Fei Formula (YQXF) is a clinically effective formula with pharmacological potential to delay the progression of COPD. This study aims to explore the relationship between the therapeutic mechanism of YQXF and the microflora in COPD. Our study found that YQXF reduces inflammatory injury and inflammatory cell infiltration in lung tissue, repairs the intestinal mucosal barrier, and enhances immune function. Additionally, YQXF regulates the pulmonary and intestinal flora by increasing the abundance of Alloprevotella, Roseburia, Oscillibacter, and Lactobacillus, while reducing the abundance of Fusobacterium, Escherichia/Shi

SUBMITTER: Han SS 

PROVIDER: S-EPMC12510709 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature