Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors.

ABSTRACT: The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for biomarker tests that can be readily used by practitioners. Although biomarker detection directly in patients' blood is now possible, low-cost point-of-care tests remain a challenge because relevant biomarkers, especially amyloid- β ( Aβ ) peptides, are small, they occur at very low concentrations, and detecting a single marker is insufficient. Here, we demonstrate a photonic resonant sensor able to detect 0.2 pg/ml of Aβ42 and Aβ40 in 1% human blood serum, equivalent to 20 pg/ml in undiluted serum, which is the clinically required level. This high performance is achieved by combining gold nanoparticle amplification with a dielectric nanopillar photonic crystal structure in a dimer con

SUBMITTER: Arruda GS 

PROVIDER: S-EPMC12510715 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature