Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study.

ABSTRACT:

Aims

This study examined the associations between decade-long cumulative blood pressure (BP) exposure and global/regional myocardial structure and function independent of current BP levels.

Methods and results

We analysed 3015 adults (aged 69.0 ± 9.2 years) from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent cardiac magnetic resonance (CMR) imaging at Year 10 (Exam 5, 2010-12). Measures included left ventricular (LV) parameters, global/regional myocardial function via tagged CMR, interstitial myocardial fibrosis via T1-mapping measures (native T1 and extracellular volume fraction), and myocardial scar via late gadolinium enhancement. We used cumulative exposure to BP through baseline and up to Exam 5 (millimetres of mercury × year) to represent long-term expo

SUBMITTER: Masrouri S 

PROVIDER: S-EPMC12510735 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature