Feasibility study of dose de-escalation in postoperative intensity-modulated radiation therapy for locally advanced thymoma.

ABSTRACT:

Purpose

This study aimed to investigate retrospectively the feasibility of reducing the standard postoperative radiation therapy (PORT) dose of 45-50 Gy for locally invasive thymoma to shorten treatment duration and minimize side effects, while preserving disease-specific survival (DSS) and progression-free survival (PFS).

Materials and methods

Between January 2016 and June 2022, 150 locally advanced thymoma patients underwent surgery followed by intensity-modulated radiation therapy, with a median follow-up of 40.8 months; the standard regimen was 45-50 Gy in 25 fractions (median biological effective dose [BED] 60 Gy), compared to a de-escalation regimen of 30-35 Gy in 10 fractions (median BED 47.25 Gy), with PFS as the primary endpoint, and overall survival (OS), DSS, and

SUBMITTER: Hur YJ 

PROVIDER: S-EPMC12510745 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature