Proximal vs. total gastrectomy for proximal advanced gastric cancer: a systematic review and meta-analysis of propensity score-matched studies.

ABSTRACT:

Background

The optimal surgical approach for locally advanced proximal gastric cancer (LAPGC) remains controversial. While total gastrectomy (TG) is widely accepted, proximal gastrectomy (PG) is increasingly considered to preserve function. This study represents the first meta-analysis to comprehensively compare the surgical and oncological outcomes of PG versus TG for LAPGC using data from propensity score-matched (PSM) studies, addressing a critical gap in surgical decision-making.

Methods

A comprehensive search of various electronic databases was conducted. Studies comparing PG and TG in LAPGC with PSM methodology were included. Pooled hazard ratios (HRs), odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CI) were calculated using a random-effects mo

SUBMITTER: Liu C 

PROVIDER: S-EPMC12510815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature