<i>Dendrobium huoshanense</i> C. Z. Tang & S. J. Cheng alleviates atherosclerosis by reducing lipid and improving vascular endothelial dysfunction.

ABSTRACT:

Introduction

Dendrobium huoshanense C. Z. Tang & S. J. Cheng (DH) water extract has previously been found to have therapeutic effects on atherosclerosis (AS), but the active ingredients responsible for these effects remain unclear. This study aims to identify the active monomers in DH water extract that can treat AS, providing a basis for its use in preventing AS.

Methods

LC-MS analysis was conducted to identify the main active ingredients in DH water extract. A zebrafish AS model was used to screen for the active ingredients with therapeutic effects. Network pharmacology was utilized to predict the mechanisms through which these active ingredients treat AS.

Results

Six main active ingredients were identified, and three, namely dendrophenol, naringenin, and api

SUBMITTER: Fan XC 

PROVIDER: S-EPMC12510864 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature