Immunoinformatics-Based Multi-Epitope Vaccine Design Against <i>P. falciparum-</i>Causing Malaria: A Computational Approach.

ABSTRACT:

Background and aim

Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin-based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study aimed to design a multi-epitope vaccine against Plasmodium falciparum (P. falciparum) using immunoinformatics and computational techniques.

Methods

In this study, we employ immunoinformatics and computational techniques to design a multi-epitope vaccine against P. falciparum. B cell epitopes, cytotoxic T (Tc) cell and helper T (Th) cell epitopes were identified from five highly conserved P. falciparum

SUBMITTER: Larbi AA 

PROVIDER: S-EPMC12510901 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature