Diagnostic accuracy of low-complexity, manual nucleic acid amplification tests for the detection of pulmonary and extrapulmonary tuberculosis in adults and adolescents: a systematic review and meta-analysis∗.

ABSTRACT:

Background

Low-complexity, manual nucleic acid amplification tests, such as loop-mediated isothermal amplification for tuberculosis (TB-LAMP), are among the molecular WHO-recommended rapid diagnostics and can provide results within a few hours, even in resource-limited settings. We aimed to synthesise evidence on the accuracy of these tests for the detection of pulmonary and extrapulmonary tuberculosis, to inform the 2024 update of the WHO consolidated guidelines on tuberculosis.

Methods

For this systematic review and meta-analysis, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, the Science Citation Index and BIOSIS previews, WHO Global Index Medicus, and Scopus databases, for articles published from Jan 1, 1946, to Oct 2, 2023, using specif

SUBMITTER: Inbaraj LR 

PROVIDER: S-EPMC12510911 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature