Circadian Variability and Its Influence on Infarct Size and Clinical Outcome Among Japanese Patients With Acute Myocardial Infarction.

ABSTRACT:

Background

There is significant circadian variation in the frequency of myocardial infarction onset, with a notable increase during the early morning. However, it remains unclear whether this circadian rhythm influences post-acute myocardial infarction (AMI) clinical outcomes and infarct size.

Methods and results

This study included 2,251 patients enrolled in the Japan AMI Registry (JAMIR) who had ST-elevation myocardial infarction (STEMI) with a documented time of onset, stratified into 4 time periods: 00:00-06:00, 06:00-12:00, 12:00-18:00, and 18:00-00:00 h. The primary outcome measure, used as an indicator of infarct size, was peak creatine kinase (CK) level. The median peak CK level among patients was 1,978 IU/L. No significant differences in peak CK levels were observed

SUBMITTER: Motokawa T 

PROVIDER: S-EPMC12510979 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature