Association of appropriate empiric antimicrobial therapy with acute kidney injury in gram-negative sepsis.

ABSTRACT:

Background

Despite advances in sepsis management, the relationship between appropriate empiric antibiotic therapy and acute kidney injury (AKI) in sepsis remains unclear. This study aimed to examine the association of appropriate empiric antimicrobial therapy with AKI in early onset sepsis caused by gram-negative bloodstream infections.

Methods

We conducted a retrospective study of gram-negative bloodstream infection episodes in adult patients with early onset sepsis, using the Premier Healthcare Database from 2016 to 2020. The exposure was appropriate empiric antibiotic therapy determined by antibiotic regiments and antimicrobial susceptibilities of pathogens. The primary outcome was development of AKI or death by day 7 after the onset of sepsis. AKI was defined using the K

SUBMITTER: Ohnuma T 

PROVIDER: S-EPMC12510998 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature