Personalized temporal interference stimulation targeting striatum reduces functional stability and dynamic connectivity variability in the sensorimotor network.

ABSTRACT:

Background

Functional stability within brain networks, particularly the sensorimotor network (SMN), is crucial for coherent motor control. Temporal Interference (TI) stimulation offers a non-invasive method to modulate deep brain structures like the striatum, yet its impact on dynamic functional stability across motor networks remains largely unexplored.

Methods

Twenty-six healthy male participants separately underwent TI stimulation and Sham stimulation in a crossover, double-blind, randomized controlled trial with counterbalanced protocol. resting-state functional magnetic resonance imaging (rs-fMRI) was acquired before and during the stimulation. A total of 20 min TI stimulation (10 mA, Δf = 20 Hz) was applied to the right striatum using personalized electrode montages op

SUBMITTER: Tang D 

PROVIDER: S-EPMC12511026 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature