The landscape of neutralizing antibodies against SARS-CoV-2 variants: Insights from a stratified vaccination cohort.

ABSTRACT:

Background

The COVID-19 pandemic has highlighted the crucial role of vaccines in preventing infection and reducing disease severity. However, emerging SARS-CoV-2 variants have posed challenges to vaccine-induced immunity.

Objective

To evaluate the immunological response and clinical characteristics of individuals with complete and incomplete COVID-19 vaccination schedules, with a focus on neutralizing antibody levels against SARS-CoV-2 variants.

Methods

A total of 245 participants were analyzed and stratified by complete and incomplete vaccination status. The complete vaccination was defined by 3 doses for <40 years or 4 doses for >40 years. Clinical data, serological responses, and neutralization levels against the Wuhan strain and the Delta and Omicron (BA.1, BA.2,

SUBMITTER: Fialho MJ 

PROVIDER: S-EPMC12511102 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature