Integrated metabolomic insights into the mechanism of <i>Bacillus coagulans</i> in enhancing intestinal recovery following gynecological laparoscopic surgery: a randomized clinical trial.

ABSTRACT:

Objective

To evaluate the efficacy and mechanistic underpinnings of live Bacillus coagulans tablets in accelerating recovery of intestinal function after gynecologic laparoscopic surgery.

Methods

A randomized, double-blind, placebo-controlled trial included 115 patients undergoing gynecological laparoscopy, assigned to placebo control (PC, n = 39), conventional dose (CD, n = 38), and high dose (HD, n = 38) groups. Clinical recovery was assessed by timing of first postoperative bowel movement and gastrointestinal adverse reactions. Plasma levels of motilin (MTL) and serotonin (5-HT) were measured using ELISA. Plasma metabolite profiles were analyzed via metabolomics to elucidate treatment-related metabolic pathways.

Results

Treatment groups

SUBMITTER: Xu J 

PROVIDER: S-EPMC12511109 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature