The efficacy and safety of extended thromboprophylaxis after colorectal surgery: a systematic review and meta-analysis.

ABSTRACT:

Purpose

To report (1) efficacy and (2) safety outcomes comparing extended thromboprophylaxis (ETP) with low molecular weight heparin (LMWH) and direct oral anticoagulants (DOAC) versus no ETP after colorectal surgery.

Methods

A systematic review using MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials to March 2024. Randomised controlled trials and observational studies investigating ETP with LMWH or DOAC for at least 28 days were included. (1) Efficacy outcome was venous thromboembolism (VTE) rate at 30-days postoperatively. (2) Safety outcomes included major bleeding events at 30-90-days. Odds ratio (OR) and 95% confidence intervals (CI) were calculated using a Mantel-Haenszel fixed effects model.

Results

Five studies (2936 patients) investigating co

SUBMITTER: Choi JDW 

PROVIDER: S-EPMC12511134 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature