Tumor and immune cell distribution in the tumor core and outer part of glioblastoma, IDH wildtype.

ABSTRACT:

Purpose

Glioblastoma, IDH-wildtype is the most frequent and malignant primary brain tumor in adults. Tumor cells infiltrate the brain parenchyma, preventing complete resection and causing progression. Immune therapies have limited effect, but little is known about the frequency and type of immune cells in the outer part of glioblastoma, IDH-wildtype, where tumor cells start to infiltrate the brain (transition zone) and diffusely infiltrate the brain parenchyma (tumor periphery). We aimed to quantify the type and distribution of immune cells in glioblastomas, IDH-wildtype covering these areas.

Methods

We established a cohort of 54 glioblastomas, IDH-wildtype containing tissue from the tumor core, transition zone, and periphery. Patients were included if most tumor cells were

SUBMITTER: Pedersen V 

PROVIDER: S-EPMC12511171 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature