Efficacy and safety of lemborexant vs placebo in treating adults with insomnia disorder: a systematic review and meta-analysis of 1976 patients.

ABSTRACT: Insomnia is a typical sleep disorder in which an individual finds it difficult to fall asleep and stay asleep resulting in poor daytime functioning and decreased health and quality of life. The orexin system, which regulates wakefulness and arousal, is often overactive in individuals with insomnia, disrupting normal sleep patterns. Lemborexant, a dual orexin receptor antagonist, works through the inhibition of the orexin system, thus facilitating increased sleep onset and maintenance of sleep. This systematic review and meta-analysis seek to determine the effectiveness and safety of lemborexant in the treatment of insomnia. A comprehensive search was conducted on PubMed, Scopus, Web of Science, and Cochrane Library, from inception to September 2024. Four randomized controlled trials (RCTs)

SUBMITTER: Alsaied MA 

PROVIDER: S-EPMC12511177 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature