Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charite LMD registry.

ABSTRACT:

Introduction and objectives

Leptomeningeal disease (LMD) involves disseminating cancer cells to the leptomeninges and cerebrospinal fluid. The impact of intracranial parenchymal brain metastases and extracranial disease burden at LMD diagnosis remains unclear. This study evaluates these factors alongside local and systemic therapies before and after LMD diagnosis.

Methods

A retrospective analysis was conducted on 188 patients diagnosed with LMD between 2011 and 2024. Data on demographics, imaging findings, and treatments were collected. Kaplan-Meier estimates were used for survival analysis, and independent prognostic factors were identified using a backward-stepwise Cox regression model.

Results

Primary cancers included breast cancer (34.0%), non-small cell lung canc

SUBMITTER: Wasilewski D 

PROVIDER: S-EPMC12511199 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature