Hypophosphatasia and Type 1 Diabetes: A Pilot Study and Review of Literature.

ABSTRACT:

Purpose of review

Hypophosphatasia (HPP) and type 1 diabetes (T1D) are both associated with low bone turnover and increased fracture risk. In this review, our objectives were to (a) discuss results of our pilot study aimed to evaluate prevalence and clinical and radiological characteristics of HPP in adults with T1D and (b) to review literature on the use of electronic medical records (EMR) for HPP case findings.

Recent findings

In our pilot study, 18 individuals had persistent low alkaline phosphatase levels (ALP) [18/1723, 1.05%]. Among 10 participants who completed the study with potential HPP and T1D, three had a pathogenic ALPL mutation (0.16% prevalence), and six had elevated serum vitamin B6. No significant differences were found in DXA-based bone density, QCT-based b

SUBMITTER: Tariq Z 

PROVIDER: S-EPMC12511211 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature