Development and validation of a predictive nomogram for leptomeningeal metastasis risk in NSCLC brain metastases: role of tumor location, driver mutations, and stereotactic radiosurgery.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) frequently metastasizes to the leptomeninges, typically following brain parenchymal metastases (BM), with a significant impact on prognosis. However, predictors of leptomeningeal metastasis (LM) development remain poorly characterized. This study aimed to identify independent risk factors for subsequent LM development and establish a predictive nomogram for clinical risk stratification.

Methods

The final analysis included 112 pathologically definite NSCLC patients with BM, treated at Sanjiu Brain Hospital between July 2014 and December 2020, who had not undergone whole brain radiation therapy before LM diagnosis. LM diagnosis was made if the patient had a history of pathologically confirmed lung cancer, new signs and symptoms of

SUBMITTER: Bashir S 

PROVIDER: S-EPMC12511215 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature