New evidence for the protective effect of gut microbiota regulation of ferroptosis-related proteins against osteoporosis.

ABSTRACT: Osteoporosis (OP), characterized by bone degradation and increased fracture susceptibility, constitutes a significant global health burden. Recent findings implicate gut microbiota and ferroptosis in the regulation of bone metabolism; however, causal evidence for the gut microbiota's influence on OP specifically via ferroptosis regulation remains to be established. This study employed two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) summary statistics to investigate these causal relationships and delineate mediating pathways.We assessed causal links between gut microbiota, ferroptosis-related proteins, and OP risk. Associations for gut microbiota abundance and ferroptosis-related proteins were derived from GWAS data and Icelandic blood-derived protein quan

SUBMITTER: Guo Z 

PROVIDER: S-EPMC12511265 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature