Cartilage mechanical responses during gait as in silico biomarkers for medial knee OA progression.

ABSTRACT: Osteoarthritis (OA) is a common degenerative whole joint disorder characterized by articular cartilage breakdown, mostly often in the knee's medial compartment. Traditional attempts to predict structural progression have focused on biochemical markers from blood, synovia, or urine; however, these do not capture internal mechanical environments that drives cartilage degeneration. In silico modelling enables non-invasive, patient-specific estimation of internal joint loading, including contact pressure, compressive strain, fibril strain and maximum shear strain, as potential mechanical biomarkers for OA progression. This study developed a novel MSK-FE workflow linking gait kinematics to contact pressures and cartilage tissue strains. Subjects showing medial OA progression over 2 years exhibi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12511356 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature