Micro-nano microbial fuel cell-driven bioelectrochemical tumor therapy.

ABSTRACT: Colorectal cancer remains one of the most challenging malignancies to treat due to its intestinal physiological barrier, extracellular interstitial barrier, and immunosuppressive tumor microenvironment. Here we develop a micro-nano microbial fuel cell system, integrating Desulfovibrio desulfuricans (Dsv) as a biological electron donor and MnO₂ as a catalytic electron acceptor, to achieve bioelectrochemical tumor modulation. The Dsv@MnO₂-NE-PEG system, featuring norepinephrine-enhanced mucosal adhesion and PEG-mediated mucus penetration, exhibits superior tumor colonization efficiency, prolonged retention, and robust anti-tumor activity. Mechanistically, this system disrupts lactate accumulation in the tumor microenvironment, catalyzes reactive oxygen species generatio

SUBMITTER: Li R 

PROVIDER: S-EPMC12511426 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature