Lactococcus lactis subsp. cremoris C60 promotes immunoglobulin a production from B cells through functional modification of dendritic cells in the intestinal environment.

ABSTRACT: Probiotics utilizing lactic acid bacteria (LAB) have gained considerable attention in recent trends promoting self-managed health. Specifically, LAB-mediated immune modulation has been a key focus due to its potential to reduce the risk of pathogenic invasion and enhance host immunity. Immunoglobulin A (IgA) plays a crucial role in innate defense against various pathogens. Although only a limited number of probiotic LAB strains have been shown to increase IgA production, this capability remains of great interest. Here, we report a new strain, Lactococcus lactis subsp. cremoris C60 (C60), which promotes IgA production through functional modulation of intestinal B cells and dendritic cells (DCs). Heat-killed (HK)-C60 increased both pro-inflammatory and anti-inflammatory cytokine productions

SUBMITTER: Okuno A 

PROVIDER: S-EPMC12511446 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature