Trends in Fomepizole Use for Acetaminophen Poisoning in the United States; 2013-2024.

ABSTRACT:

Background

Fomepizole has been suggested as adjunctive therapy for severe acetaminophen poisoning though clinical efficacy is unknown. We sought to determine trends in the use of fomepizole for acetaminophen poisoning.

Methods

This is a cross-sectional analysis of hospitalized patients with acetaminophen poisoning from January 2013 through December 2024, using Epic Cosmos, a research database of 298 million patients nationally. We identified encounters involving acetaminophen poisoning by International Classification of Diseases, version 10 (ICD-10-CM) code. Data extracted included administration of N-acetylcysteine (NAC) and fomepizole, demographic data, and outcomes of death and liver transplantation. Data were analyzed using descriptive statistics to identify trends and m

SUBMITTER: D'Aloia M 

PROVIDER: S-EPMC12511483 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature