Fermentation process optimization of a bacteriostatic Bacillus coagulans based on response surface methodology.

ABSTRACT: Bacillus coagulans is a spore-producing lactic acid bacterium with strong stress resistance. It has been widely used in food preservation, food fermentation, livestock diarrhea prevention, medication-assisted treatment, pollutant removal et al. In the study, a Bacillus coagulans strain with superior inhibition on Staphylococcus aureus, Escherichia coli, Vibrio parahaemolyticus and Aeromonas hydrophila was screened. Its medium composition and culture conditions were optimized in flasks using single factor experiment, Plackett Burman experiment, minimum addition experiment and response surface analysis experiment. The optimal medium composition was determined to be 14.64 g/L molasses, 0.4848 g/L MgSO₄, 0.0833 g/L MnSO₄, 1.5 g/L K₂HPO₄, 0.5 g/L KCl,

SUBMITTER: Li Y 

PROVIDER: S-EPMC12511497 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature