External Validation of the Post-Biopsy International IgA Nephropathy Prediction Tool Models over Extended Follow-Up in an Asian Cohort.

ABSTRACT:

Introduction

The post-biopsy International IgA Nephropathy Prediction Tool (IIgAN-PT) models were updated to assess progression risk 1 or 2 years after biopsy. This study externally validated both models in a contemporary Asian cohort with extended follow-up to evaluate long-term predictive performance.

Methods

We included 1,296 Chinese patients with biopsy-proven IgAN. The primary outcome was a composite of end-stage kidney disease or a 50% decline in estimated glomerular filtration rate (eGFR) within 1 year post-biopsy. Model performance was evaluated using the coefficient of determination (R ²) and Akaike information criterion to assess model fit, concordance statistics (C-statistics) and Kaplan-Meier survival curves for discrimination, and the integrate

SUBMITTER: Xu L 

PROVIDER: S-EPMC12511542 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature