Identification of isoliquiritigenin as a promising compound targeting lactate metabolism for heart failure alleviation.

ABSTRACT: Lactate metabolism plays a pivotal role in heart failure (HF) progression by exacerbating cardiac fibrosis and dysfunction. However, a systematic analysis of candidate compounds targeting lactate metabolism in HF has not been conducted. Initial animal experiments demonstrated that sodium lactate supplementation ameliorated cardiac function in transverse aortic constriction (TAC) mice (all P < 0.05), whereas lactate dehydrogenase A (LDHA) inhibition impaired cardiac function in sham-operated controls (all P < 0.05), establishing lactate metabolism as a critical therapeutic target. Through integration of 335 lactate metabolism-related genes from the MSigDB with HF-associated genes from six Gene Expression Omnibus (GEO) datasets and GeneCards, we employed Connectivity Map to screen candidate

SUBMITTER: Liang J 

PROVIDER: S-EPMC12511553 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature