Breast microcalcifications as indicators of bone metastasis risk in early-stage breast cancer.

ABSTRACT: Bone metastasis is a leading cause of reduced survival in patients with advanced breast cancer. Therefore, identifying prognostic markers for bone metastasis at early disease stages is crucial. Microcalcifications are common findings in mammographic imaging and often serve as early diagnostic indicators. Certain types of microcalcifications have been linked to unfavorable genetic and molecular tumor profiles and are associated with poor prognosis. In particular, calcifications located within large ducts-such as casting-type, duct-centric patterns-have been described as independent markers of adverse outcome when compared to tumors with other calcification types or without calcifications. This study evaluated the prognostic significance of anarchic microcalcifications, defined as calcificat

SUBMITTER: Giorello MB 

PROVIDER: S-EPMC12511638 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature