Helicobacter pylori Infection and Eradication in Relation to Gastroesophageal Reflux Disease.

ABSTRACT:

Background and aim

The effect of Helicobacter pylori (H. pylori) infection and eradication on the risk of gastroesophageal reflux disease (GERD) is still unclear.

Methods

We conducted a systematic review with a comprehensive literature search in the bibliographic databases Embase, Medline, and Cochrane Library through May 2024. Random-effects meta-analyses estimated the pooled odds ratios (OR) for the associations of H. pylori infection and eradication with GERD risk in prospective studies. A two-sample Mendelian randomization analysis based on data from the FinnGen study assessed associations between genetically predicted levels of seven H. pylori antibodies, that is, immunoglobulin G (IgG) and six virulence factors (cytotoxin-associated gene A [CagA], Outer Membrane Protei

SUBMITTER: Wang H 

PROVIDER: S-EPMC12511830 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature