Exosomal miRNA profiling in chickens infected with highly and low pathogenic avian influenza viruses.

ABSTRACT:

Importance

Avian influenza virus (AIV) has emerged as a serious threat worldwide. In poultry, AIV can be divided into highly pathogenic AIV (HPAIV) and low pathogenic AIV (LPAIV). Exosomes are small vesicles released from donor cells that transmit cargo such as microRNAs (miRNAs), where exosomal miRNA can regulate target gene expression.

Objective

By profiling exosomal miRNAs from chickens infected with HPAIV and LPAIV, we provide insights into the immunological functions of exosomal miRNAs in AIV infection as well as into the development of strategies for its control.

Methods

This study analyzed the exosomal miRNA expression profiles of non-infected, LPAIV-infected, and HPAIV-infected chickens using small RNA sequencing. miRDB and Gene Ontology (GO) were used to pred

SUBMITTER: Kim C 

PROVIDER: S-EPMC12511887 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature